Obstacles and advances in SARS vaccine development
Identifieur interne : 004427 ( Main/Exploration ); précédent : 004426; suivant : 004428Obstacles and advances in SARS vaccine development
Auteurs : Deborah R. Taylor [États-Unis]Source :
- Vaccine [ 0264-410X ] ; 2006.
Descripteurs français
- KwdFr :
- MESH :
- génétique : Virus du SRAS.
- immunologie : Vaccins antiviraux, Vaccins synthétiques, Vaccins à ADN, Virion, Virus du SRAS.
- sang : Anticorps antiviraux.
- Pascal (Inist)
- Wicri :
- topic : Vaccin.
English descriptors
- KwdEn :
- MESH :
- chemical , blood : Antibodies, Viral.
- genetics : SARS Virus.
- immunology : SARS Virus, Vaccines, DNA, Vaccines, Synthetic, Viral Vaccines, Virion.
- Animals, Disease Models, Animal, Humans.
Abstract
The emergence of the severe acute respiratory syndrome (SARS) that resulted in a pandemic in 2003 spurred a flurry of interest in the development of vaccines to prevent and treat the potentially deadly viral infection. Researchers around the world pooled their scientific resources and shared early data in an unprecedented manner in light of the impending public health crisis. There are still large gaps in knowledge about the pathogenesis of this virus. While significant advances have been made in the development of animal models, the practicality of their use may be hampered by a lack of pathological similarity with human disease. Described here are issues related to progress in vaccine development and the obstacles that lie ahead for both researchers and regulatory agencies.
Affiliations:
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Le document en format XML
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Taylor</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologies Evaluation and Research (CBER), U.S. Food and Drug Administration, 8800 Rockville Pike, HFM-310</s1><s2>Bethesda, MD 20892</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Vaccine</title><title level="j" type="abbreviated">Vaccine</title><idno type="ISSN">0264-410X</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Vaccine</title><title level="j" type="abbreviated">Vaccine</title><idno type="ISSN">0264-410X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal model</term><term>Animals</term><term>Antibodies, Viral (blood)</term><term>Coronavirus</term><term>Disease Models, Animal</term><term>Humans</term><term>SARS Virus (genetics)</term><term>SARS Virus (immunology)</term><term>Severe acute respiratory syndrome</term><term>Vaccine</term><term>Vaccines, DNA (immunology)</term><term>Vaccines, Synthetic (immunology)</term><term>Viral Vaccines (immunology)</term><term>Virion (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antiviraux (sang)</term><term>Humains</term><term>Modèles animaux de maladie humaine</term><term>Vaccins antiviraux (immunologie)</term><term>Vaccins synthétiques (immunologie)</term><term>Vaccins à ADN (immunologie)</term><term>Virion (immunologie)</term><term>Virus du SRAS (génétique)</term><term>Virus du SRAS (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Vaccins antiviraux</term><term>Vaccins synthétiques</term><term>Vaccins à ADN</term><term>Virion</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>SARS Virus</term><term>Vaccines, DNA</term><term>Vaccines, Synthetic</term><term>Viral Vaccines</term><term>Virion</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Humans</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Animaux</term><term>Coronavirus</term><term>Humains</term><term>Modèles animaux de maladie humaine</term><term>Vaccin</term><term>Modèle animal</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Vaccin</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The emergence of the severe acute respiratory syndrome (SARS) that resulted in a pandemic in 2003 spurred a flurry of interest in the development of vaccines to prevent and treat the potentially deadly viral infection. Researchers around the world pooled their scientific resources and shared early data in an unprecedented manner in light of the impending public health crisis. There are still large gaps in knowledge about the pathogenesis of this virus. While significant advances have been made in the development of animal models, the practicality of their use may be hampered by a lack of pathological similarity with human disease. Described here are issues related to progress in vaccine development and the obstacles that lie ahead for both researchers and regulatory agencies.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Maryland</li></region></list><tree><country name="États-Unis"><region name="Maryland"><name sortKey="Taylor, Deborah R" sort="Taylor, Deborah R" uniqKey="Taylor D" first="Deborah R." last="Taylor">Deborah R. Taylor</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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